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In both trialsoverall survivaltime to progression and response ratecomplete plus partial responseswere assessedResponses were defined by the World Health Organization criteria and submitted to a blinded independent review committeeIRCDifferences in assessments between the investigator and IRC were reconciled by the sponsorblinded to treatment armaccording to a specified algorithmSurvival was assessed based on a non-inferiority analysis.

Withhold or permanently discontinue XELODA based on clinical assessment of the onsetduration and severity of the observed toxicities in patients with evidence of acute early-onset or unusually severe toxicitywhich may indicate near complete or total absence of DPD activityNo XELODA dose has been proven safe buy doxycycline online, buy zithromax online. for patients with complete absence of DPD activityThere is insufficient data to recommend a specific dose in patients with partial DPD activity as measured by any specific test.

Withhold or permanently discontinue XELODA based on clinical assessment of the onsetduration and severity of the observed toxicities in patients with evidence of acute early-onset or unusually severe toxicitywhich may indicate near complete or total absence of DPD activityNo XELODA dose has been proven safe for patients with complete absence of DPD activityThere is insufficient data to recommend a specific dose in patients with partial DPD activity as measured by any specific test.

This treatment might harm a baby developing in the wombIt is important not to become pregnant or father a child while you are having treatment and for a few months afterwardsTalk to your doctor or nurse about effective contraception before starting treatment.

Table 19 Response Rates in Doubly-Resistant Patients Single-Arm Breast Cancer Trial.

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